Bioactive Small Molecules
Medchemexpress LLC Odq | 41443-28-1 | MFCD00792620 | 99.8% | 187.16 g/mol | C9H5N3O2 | 10 MG
ODQ is a selective inhibitor of soluble guanylyl cyclase (sGC) used in biochemical and cell biology research to block nitric oxide-stimulated cyclic GMP production and to probe NO-cGMP signaling. It has been used to investigate sGC-dependent pathways and may enhance cisplatin-induced apoptosis in some cellular models.
- Selective inhibitor of soluble guanylyl cyclase for NO-cGMP pathway studies.
- High purity suitable for biochemical and cell-based assays.
- Available as a powder and as pre-made DMSO solution for convenience.
- Recommended storage supports multi-year stability for powder and long-term storage in solvent.
- Supplied with SDS, COA, H NMR, and LC-MS data for quality control.
CYTION U-343 MG Cells, 1 cryovial, Organism- Human, Tissue- Brain, Disease- Glioblastoma
The U-343 MG cell line is derived from a human glioblastoma, a type of aggressive brain tumor. Originally isolated from a 54-year-old Caucasian male, this cell line has been widely used in neurological research, particularly in studies concerning the pathology and therapeutic treatment strategies for glioblastoma. The U-343 MG cell line is notable for its astrocytic properties, resembling those of astrocytes in the brain, which makes it particularly useful for studying tumor behavior and neurobiology in a controlled in vitro environment.Genetically, the U-343 MG cells are characterized by various mutations typical of glioblastoma, including alterations in the TP53 gene and the EGFR gene. These mutations not only offer insights into the molecular underpinnings of glioblastoma malignancy but also serve as potential targets for therapeutic intervention.
Apexbio Technology LLC Entecavir Hydrate, 25mg. Cas: 209216-23-9 MFCD: MFCD09754448. Antiviral drug used in hepatitis B infection
Entecavir hydrate is a reverse transcriptase inhibitor.Reverse transcriptase (RT) is used to generate complementary DNA (cDNA) from an RNA template, which is mainly associated with retroviruses, such as HBV. Other sizes are available. Please inqury us for quote.
Medchemexpress LLC Thymalfasin (Thymosin α1) | 62304-98-7 | 99.3% | 3108.28 | 1 MG
Thymalfasin is an immunomodulating agent that can enhance the Th1 immune response. It has demonstrated efficacy in experimental models of immune dysfunction, including infectious diseases like hepatitis and influenza, and cancers such as melanoma and colorectal carcinoma, where it exhibits antitumor effects.
- Immunomodulating agent: Enhances the Th1 immune response.
- Effective in experimental models for infectious diseases (e.g., hepatitis, influenza) and various cancers (e.g., melanoma, colorectal carcinoma).
- Demonstrates antitumor effects in cancer models.
- High purity: 99.25%.
- Available in multiple sizes.
Medchemexpress LLC TRPM8 antagonist 3 | 2102179-29-1 | 99.51% | C13H12N2O4S | 1 ML
TRPM8 antagonist 3 is a novel TRPM8 blocker with an IC50 value of 11 nM.
- Appearance: solid
- Color: off-white to light yellow
- Molecular weight: 292.31
- Soluble in DMSO at 25 mg/mL (85.53 mM), requiring ultrasonic. Note that hygroscopic DMSO has a significant impact on solubility, so newly opened DMSO should be used.
- Storage conditions for powder: -20°C for 3 years
- Storage conditions for solutions: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC GNE-149 | 1953132-75-6 | 99.2% | C28H33F4N3O | 1 ML
GNE-149 is an orally bioavailable full antagonist of estrogen receptor α (ERα; IC50=0.053 nM). It is a selective estrogen receptor degrader (SERD) and can be used for the research of breast cancer.
- Appearance: solid
- Color: white to light yellow
- Shipping: room temperature in continental US; may vary elsewhere
- Storage: 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light)
Medchemexpress LLC SR-BI/SCARB1 Human | 50UG
The SR-BI/SCARB1 protein is a multifunctional receptor that binds a variety of ligands including phospholipids cholesteryl esters lipoproteins phosphatidylserine and apoptotic cells As an HDL receptor it crucially mediates selective cholesterol ether uptake and HDL-dependent cholesterol efflux SR-BI/SCARB1 Protein Human (HEK293 His-Fc) is the recombinant human-derived SR-BI/SCARB1 protein expressed by HEK293 with C-hFc C-His labeled tag
![eMolecules 2924824-04-2 | Desthiobiotin-Iodoacetamide | Medchem Express | 424.283 | C14H25IN4O3 | 98 | C[C@@H]1NC(=O)N[C@@H]1CCCCCC(=O)NCCNC(=O)CI | 5mg | 779715359](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC2328617.JPG-250.jpg)
eMolecules 2924824-04-2 | Desthiobiotin-Iodoacetamide | Medchem Express | 424.283 | C14H25IN4O3 | 98 | C[C@@H]1NC(=O)N[C@@H]1CCCCCC(=O)NCCNC(=O)CI | 5mg | 779715359
ChemScene | 2-Methylbenzo[d]oxazol-5-amine | 250mg | 711934202 | CS-0035772 | 72745-76-7 | MFCD00628970 | 148.165 | C8H8N2O
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Medchemexpress LLC Jnj-61803534 | 1917306-14-9 | 99.8% | 622.41 | 1 ML
JNJ-61803534 is a potent and orally active RORγt inverse agonist with an IC50 of 9.6 nM. It exhibits anti-inflammatory activity and inhibits IL-17A production in human CD4+ T cells under Th17 differentiation conditions. It also inhibits RORγt transcription in HEK-293 T cells.
- Potent and orally active RORγt inverse agonist.
- IC50 of 9.6 nM against RORγt.
- Anti-inflammatory activity.
- Inhibits IL-17A, IL-17F, IFNγ, and IL-22 production in CD4+ T cells.
- Alleviates inflammation, cartilage damage, bone destruction in mouse collagen-induced arthritis (CIA) model.
- Alleviates Imiquimod-induced dermal psoriatic-like inflammation in mice.
Medchemexpress LLC Sincalide | 25126-32-3 | MFCD00079849 | 98.7% | 1143.27 | 1 MG
Sincalide, also known as Cholecystokinin octapeptide (CCK-8), is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK). It is intended for intravenous use in postevacuation cholecystography and retains most of CCK's biological activities.
- Promotes gallbladder contraction
- Helps diagnose gallbladder and pancreas disorders
- Increases bile secretion and relaxes the sphincter of Oddi
- Inhibits myocardial fibrosis and reduces inflammation and apoptosis
- Protects H9c2 cardiomyoblasts from Ang II-induced apoptosis via CCK1 receptor and PI3K/Akt pathway
- Alleviates fibrosis and delays left ventricular remodeling in MI rat models
- For research use only
Medchemexpress LLC KP-457 (GMP) | 1365803-52-6 | 480.55 | 100 MG
KP-457 (GMP) is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor. Produced using GMP guidelines, this small molecule serves as an auxiliary reagent for cell therapy manufacture, offering higher selectivity for ADAM17 compared to other MMPs and ADAM10.
- Selective ADAM17 inhibitor
- Manufactured under GMP guidelines
- Auxiliary reagent for cell therapy
- Demonstrates higher selectivity for ADAM17 over other MMPs and ADAM10
Cayman Chemical Pirodavir, Purity: ≥98%, CAS: 124436-59-5, 25 mg
A broad-spectrum antipicornaviral agent; active against 80 typed (MICs = 0.001-14.4 µg/ml) and one untyped rhinovirus strain (MIC = 0.002 µg/ml); active against serotypes of coxsackievirus, poliovirus, and echovirus enteroviruses (MICs = 0.018-8.5, 0.025-0.27, and 0.019-1.3 µg/ml, respectively)
Medchemexpress LLC GNE-617 hydrochloride | 1362154-70-8 | ≥98.0% | 427.42 g/mol | C21H15F2N3O3S | 10 MG
GNE-617 hydrochloride is a potent, selective small-molecule inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with reported biochemical potency in the low nanomolar range. It is supplied as the hydrochloride salt and is used for in vitro NAMPT assays, antiproliferative studies, and in vivo xenograft models.
- Potent NAMPT inhibition (IC50 ≈ 5 nM).
- Hydrochloride salt supplied as a solid powder.
- Typical purity ≥98% (supplier dependent).
- Molecular formula C21H15F2N3O3S; molecular weight 427.42 g/mol.
- Suitable for in vitro and in vivo cancer biology research.
- CAS number 1362154-70-8.
Cayman Chemical CGRP (8-37) (mouse, rat) (trifluoroacetate salt), Purity: ≥95%, 5 mg
A CGRP receptor antagonist; selectively binds to heterotrimeric complexes of CRLR and RAMP1 or RAMP3 over a complex of CLCR and RAMP2 (IC50s = 1, 6.2, and 219 nM, respectively); prevents CGRP-induced increases in heart rate and decreases in blood pressure in transgenic mice expressing rat CRLR in smooth muscle-containing tissues and sympathetic ganglia at 2 µmol/kg; inhibits p-phenylquinone-induced writhing (ED50 = 6 µg/animal) and decreases body temperature in mice
Apexbio Technology LLC Vincristine sulfate, 5mg. Cas: 2068-78-2 MFCD: MFCD08706469. Microtubule disrupter,antitumor agent
Vincristine is a naturally occurring alkaloid that potently inhibits the tubulin addition with the inhibition constant Ki value of 0.085 M and exhibits an anti-proliferative activity against B16 melanoma cells with the half maximal inhibition concentration IC50 value of 0.45 M [1]. Other sizes are available. Please inqury us for quote.