Bioactive Small Molecules
Cayman Chemical ANTIBODY NIBR0213 1mg
A potent and selective S1P1 antagonist (IC50s = 2.5 and 2.0 nM for hS1P1 Ca2+ mobilization and in a GTPγS assay); inactive at S1P2, S1P3, and S1P4 receptors (IC50s = >20, >10, and >10 µM, respectively in a Ca2+ mobilization assay); reduces EAE disease severity in mice up to 26 days; induces pulmonary damage in rats when administered chronically
Cayman Chemical ANTIBODY ChlorIn e6 100mg
A photosensitizer; active against S. aureus, P. aeruginosa, E. coli, and S. typhimurium when used at 20 µM in combination with PDT; induces tumor regression when combined with PDT in several sarcoma rat xenograft models at 5 and 10 mg/kg
Medchemexpress LLC EphB3 protein, rat (HEK293, C-terminal His tag) | >95.0% | 50 UG
Recombinant rat EphB3 protein expressed in HEK293 cells and purified with a C-terminal His tag. Supplied as purified protein for research use; purity greater than 95% (reducing SDS-PAGE), suitable for biochemical and cell-based studies.
- Recombinant rat EphB3 expressed in mammalian cells to preserve post-translational modifications.
- C-terminal His tag for straightforward detection and purification.
- High purity (>95%) suitable for biochemical and cell-based assays.
- Available in small and larger pack sizes to accommodate experimental scale.
- Suitable for receptor binding, signaling pathway, and antibody validation studies.
Cayman Chemical ANTIBODY SU11274 500ug
A potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM); induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines
Abcam Dasatinib, Src family tyrosine kinase (SFK)/Bcl-Abl kinase inhibitor, 25MG
MW 488 Da, Purity >98%. Potent Src family tyrosine kinase (SFK)/Bcl-Abl kinase inhibitor.Inhibits growth of Bcr-Abl–dependent chronic myeloid leukemia xenografts in nude mice. Anti-tumor activity *in vivo*.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC HY-131454 5mg Medchemexpress, SR-717 CAS:2375421-09-1 Purity:>98%
Medchemexpress, HY-131454 5mg SR-717 CAS:2375421-09-1 SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC (E)-Flavokawain A | 37951-13-6 | MFCD00017174 | 20 MG
(E)-Flavokawain A is a chalcone extracted from Kava with significant anticarcinogenic effects. This compound has been shown to induce apoptosis in bladder cancer cells via a Bax protein-dependent and mitochondria-dependent pathway, effectively suppressing tumor growth in mice. It is intended for research use only.
- Chalcone extracted from Kava
- Exhibits anticarcinogenic effects
- Induces apoptosis in bladder cancer cells
- Suppresses tumor growth in mice
- Purity of 99.53%
- Molecular weight of 314.33
- Chemical formula C18H18O5
- Appears as a light yellow to yellow solid
- Store at 4°C, protected from light
- When in solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light
Apexbio Technology LLC Celastrol, 5mg. Cas: 34157-83-0 MFCD: MFCD03424073. Antioxidant, anti-inflammatory and immunosuppressive agent
Celastrol is a potent proteasome inhibitor [1].Proteasomes are protein complexes that degrading unneeded or damaged proteins by proteolysis.Celastrol is a potent proteasome inhibitor and an antioxidant, anti-inflammatory and immunosuppressive agent. Other sizes are available. Please inqury us for quote.
![Medchemexpress LLC 4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]morpholine | 700874-71-1 | ≥98.0% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230119.png-250.jpg)
Medchemexpress LLC 4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]morpholine | 700874-71-1 | ≥98.0% | 50 MG
LY2109761 is an orally active small-molecule dual inhibitor of transforming growth factor-β (TGF-β) receptor type I and II used for research applications. It shows Ki values of 38 nM for TβRI and 300 nM for TβRII, and is supplied as a powder for analytical and research use.
- Orally active TGF-β receptor type I/II inhibitor
- Ki values of 38 nM (TβRI) and 300 nM (TβRII)
- Powder form suitable for analytical and research use
- Molecular formula C26H27N5O2; molecular weight 441.52 g/mol
- Soluble in DMSO (6.67 mg/mL) and suspendable in 0.5% CMC-Na/0.5% Tween-80 (1 mg/mL)
- Stable when stored as a powder at -20°C for long-term storage
Medchemexpress LLC HY-N6022 5mg Medchemexpress, Byakangelicin CAS:482-25-7 Purity:>98%
Medchemexpress, HY-N6022 5mg Byakangelicin CAS:482-25-7 Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of drug-drug interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
TARGETMOL CHEMICALS INC CDPPB 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5). purity: 99%
Abcam Ibuprofen, NSAID, 5G
MW 206.28 Da, Purity >99%. A nonsteroidal anti-inflammatory drug (NSAID). Non-selective inhibitor of COX-1 and COX-2 (IC₅₀ values are 12 and 80 μM respectively). Inhibits thromboxane B2 release (IC₅₀ = 1.27 μM) and anandamide metabolism (IC₅₀ = 400 μM).
The product is subject to the following: Abcam Restricted Use Statement